Trimethoprim Causes Liver Malfunction
Jul 7, 2010
My son was prescribed Trimethoprim by dermatologist for acne ! He became very sick short of breath etc ended up in hospital and they did tests on his liver and they were very high stopped tablets they did not think it was them took liver results a few days later normal then started taking tablets again and liver results were very high . WE have done research on these tablets and in some cases they can cause liver malfunction. DO NOT TAKE THEM
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I was given 2 doses of 7 day doses of regular antibiotics to get rid of a suspected kidney infection & chest infection . I have a weakened immune system and liver disease . I read the side effects and it tells you to not take it if you have liver disease . The doctor who prescribed them knows of my other Illnesses and medication/s .
I thought I'd google Trimethoprim and came accross this site as it states Not to take them if you have Liver disease , which I have .
I am on a 7 day course of 200 twice a day and am taking my first dose tonight . I will keep everyone informed Daily of my progress and will also update you on the upsides and downsides of taking this medication.,,,
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I had my gallbladder removed laparascopically 2.5 years ago. Have had some issues with diarrhea but nothing else. About 3 weeks ago I was diagnosed by my PCP based on my symptoms with gastritis due to Nsaid overuse. Have been on a PPI and Carafate. Not improving at all, in fact getting worse. My ALT liver enzyme was slightly high but otherwise the rest of the blood work was normal.
Went back to see my PCP today and she brought up the subject, based on my symptoms, of possible Sphincter of Oddi malfunction. My symptoms are RUQ pain that comes and goes, yellow stool, stomach bloating and nagging upper back pain between shoulder blades. I have an ultrasound on Friday. After reading about SOD (shudder) I think this might be just the beginning of the saga if I do indeed have it.
Do any of you dear readers have any experience or knowledge in this area?
It is a good thing I am retired because I have been basically sacked out on the couch. I think it would be impossible to work with the degree of discomfort I am having.
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I have been diagnosed with Chronic Prostatitis and prescribed a 28 day course of 200 mg Trimethoprim tablets along with 2.5mg of Oxybutynin for the same period. Started the treatment several days ago having taken 4 tablets of each drug.There are no immediate side effects apart from a slight dizzyness. Having read the posts about the bad reactions to this drug,it has given me great concern over the long period I have to take these tablets. Are there any other readers to this website who have taken this drug for the same period of about a month ?
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My mother is a 65 year old female, 136 lbs, and on peritoneal dialysis for 3 years due to End Stage Renal Disease. Last week, she began experiencing severe abdominal pain that was a burning/gnawing pain. She went to the hospital and a CT Abdomen was taken without contrast. All was normal.
Over the next four (4) days, the pain persisted, particularly during dialysis exchanges at home. She returned to the hospital who admitted her. Another CT Abdomen was taken at this time which showed "nodular contour on the liver", free air in transverse colon which appeared to be dilated. She was also constipated for several days during this period. The CT impression suggested clinical evaluation for chronic liver disease.
A standard liver panel was taken and all results were normal. Nothing even close to elevated. She has never had a history of any liver issues and never had anything show on a CT for liver. After a day in the hospital, all stomach pain disappeared, she was able to use the restroom, and all stool samples/GI tests were normal without blood. She is naturally anemic due to ESRD with low iron/protein. Her last ANA/autoimmune panel was in December, all clear. No history of any hepatitis.
An Ultrasound Right Upper Quadrant was performed and the impression was no biliary obstruction, moderate ascites (tends to be normal due to peritoneal dialysis fluid), and "heterogeneous liver." The impression suggested referral for cirrhosis evaluation.
She began taking Hydralazine (25mg/3 times daily) in the last 3-4 months. She also takes a host of other blood pressure medicines.
QUESTION: She is currently awaiting a kidney transplant and very worried about this. A blood test will be taken in a couple weeks by a specialist that is supposed to diagnose Cirrhosis. Given this presentation alone, what other causes could explain this imaging results? Should we fear the worst?
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I had an abdominal ultrasound done for some abdominal pain and it was noted in the report as an impression that I had an echogenic appearing liver (such as non alcoholic fatty liver). My doctor at that time didn't tell me and just said my report was normal. When I went in for my Colonoscopy that was unrelated, it was mentioned again and when I did some research I realized what fatty liver actually was. I switched doctors.
My new doctor is considering giving me a CT scan but is checking with the GI department to see if they think its needed, etc. etc. But that there is no treatment for it besides diet modification.
Here's the thing. I don't have any of the risk factors. I am not overweight. I'm actually underweight slightly (BMI is 18, I weigh 110 lbs). I don't drink any alcohol, never did. And I don't have diabetes or hepatitis. The only thing I could do and what I have been doing is change my diet. I stopped eating processed foods, watched my sugar/carbs, and eat more vegetables than I ever have.
I'm a very anxious person and I'm not sure I want to know what the scan says. If it's worse than what I thought, I'm going to be so upset and stressed out. And I can't treat it anyway. It's not like they can give me a medication and make it go away. I think knowing the extent of it will just cause me mental anguish and I'm already stressed out about it as is.
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My Cholesterol was 7.8 and I was put on Statins 3 years ago. Because they gave me pains in my legs and other areas I stopped them.
A year ago my Cholesterol was still high and I had changed doctors and was prescribed Atorvastatin 10 mg after 2 months my doctor sent me for blood tests and in a phone call when I was at work he told me that Atorvastatin had caused Liver damage. He said I should stop taking the tablets immediately, pity this advice was not put on my notes so that when I phoned for my blood results a week earlier the receptionist could inform me to stop Atorvastatin. She just said Doctor will be in touch via phone call next week
He referred me to a Liver Specialist.
I went to see Liver Specialist after having Liver Ultrasound. Fatty liver was diagnosed and Liver Specialist promptly put me back on Atorvastatin claiming this would help my fatty liver. I couldn't believe it but what could I do?
Local GP had advised me to have bloods done again after being on tablets for 2 months. When my results came back the Locum doctor I saw said "whoa your Liver is not happy" STOP the tablets and have a blood test in 2 weeks.
2 weeks later Liver levels are coming down so thats a good direction. Dilemma is I have to see my Liver Consultant 16 June 2015. Wish me luck!
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this isn't about me but is about my girlfriend who is about to have gastric sleeve surgery.
She is a 40 year old women that has had a full hysterectomy and has type 2 diabetes. she has had a history of thyroid and weight issues. she is 5,7 weighs 225 LBS. she has an enlarged fatty liver of 27cm and the Doctor said that she needs "emergent" gastric sleeve surgery to bring down her enlarged liver. this was claimed on this past thursday. I have been looking high and low for documentation and statistics on using the surgery for reducing fatty livers but can't find any information. Does this sound right? has there been a history of using this procedure for such cases, I'm worried and scared for her.
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Been feeling lightheaded and brain foggy and a bit sick recently with some stomach grumbling and pain. Went to the doctors who did repeat blood tests over the course of 8 weeks and have said my enzymes are slightly up which could be the result of mild fatty liver. My question is does this sound related? He's also just tested me for celiac, but told me in the beginning that I could be fighting a virus. I'm worried that the 3 diagnoses he's given are so different I don't know what to believe, also does this mean I should be less worried about the tests because they are low enough to be anything?
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I've recently had 2 LFT that both showed raised enzymes, I've had a scan and it shows I have gallstones, however I am currently undergoing investigation into whether I have Reactive Hypoglycaemia, my question is that if I do have RH, would this cause my liver enzymes to elevate?
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IiIt was picked up by chance thaI have fatty liver, could have had this for years without knowing about it, how do I find out how much damage has been done already if any? My GP does not seem too concerned about it, all my LFT have come back normal so what can I do about it apart from lifestyle change which I'm doing already?
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Just before christmas I received a letter from my hospital saying “ recent blood tests show a slightly abnormal liver function and the scan revealed cirrhosis. It is absolutely crucial that you consider urgently reducing your alcohol intake to avoid further liver damage. I would be grateful if you could see your gp to discuss this further.”
Immediately I phoned my gp and couldn’t get an appointment for 2 weeks, when finally seeing my gp she referred me to a councillor, which took another 2 weeks before I saw them, only to be told they don’t have a clue at what stage my cirrhosis is?
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I was prescribed a 3 day course of Trimethoprim for a UTI I took the first one on a Tuesday night and by Wednesday morning i had a numb left knee, the next day i couldn't walk, phoned my GP asking if i should continue on the antibiotic because it seemed obvious to me that i was having a bad reaction to it. I was told to continue the course but wish i hadn't, the pain on Thursday night was unbearable in my left leg, i couldn't move it and it was hugely swollen. On Friday morning i went to hospital and was there for 5 days on more antibiotics and painkillers. it's been 5 weeks now and i still can't walk on my left leg i still have pain and it also started in my right hand too. Before taking Trimethoprim i was a healthy 43 year old woman with no health issues. I'm now waiting to see a Rheumatologist and am terrified my leg won't recover.
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I had a very bad experience with Trimethoprim and I only took it for 3 days It affected my breathing has anyone else had this side affect?
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This was prescribed to me for a urinary tract infection from an operation which needed a catheter. Hence the infection about 2 weeks later.
I have just finished the course which towards the end made me feel really washed out and lethargic, but if it cured the problem, that is all that mattered.
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Should you avoid alcohol with these tablets, or is small alcohol consumption ok with them ?
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I was prescribed this drug yesterday for a supposed urine infection. I had suffered with urine infections alot in my teens and into adulthood, however had not had an infection since having my son 8 years ago. I had problems during my pregnancy high blood pressure being one of these problems. As a result I only have one fully functional kidney. I was told that my blood pressure would probably go up again in later life and therefore have had it checked each year since.
On a routine checkup a couple of weeks ago, it appears that the high blood pressure is back and at the checkup I also had my urine dipped. The nurse asked me if I had any problems passing water etc. When I said I hadn't, she said there was something in my water and would send it off to the hospital just in case. I said that I thought I would have noticed if there had been a problem.
Anyway, yesterday I got the results and the surgery informed me that my doctor had left a prescription out for me. I picked it up and took the first tablet at four o'clock. By seven o'clock I had a severe headache, and the most awful chest pain, I thought I was having a heart attack
On reading the side effects we rang the hospital, got an appointment, by which time my back and chest were covered in a rash. My Blood pressure had reached 240/140 extremely high....
The doctor confirmed that it was an allergic reaction to trimethoprim and injected me with an antihistamine. Having checked my urine again, they said I did not have an infection in the first instance and should never have been prescribed this drug and confirmed that it could have been fatal.
I am going to make a formal complaint to my doctor and would like to take this further. Why is this drug being prescribed? I think I am very lucky to be here today and my children could have been left without their mum.
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I was prescribed a 3 day course of Trimethoprim, for cystitis, which I have suffered from many times before in the past. However, this time the medication made me extremely nauseous. Within about 10 minutes of taking the tablet I began retching violently and about an hour later developed a very itchy red rash on the inside of my lower arms. The rash gradually disappeared over about an hour but every time I took another tablet (two per day) I started to retch violently. I have taken the last tablet this evening but have now woken at 3.30am feeling sick again. I wish I had read your website sooner as I now realise I am far from alone in my reaction to this drug. I find it strange that I have taken it many times in the past without any obvious side effects.
[i:f8ec489ea7]This message was automatically imported from the original Patient Experience[/i:f8ec489ea7]
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I've just been prescribed trimethoprim for UTI and after reading all the posted I'm so afraid of taking them. I had a reaction to norethisterone just over a year ago and it was not very nice at all and I don't want to feel that ever again. But if I don't take these tablets then I'm worried I'll still have the UTI. Is it worth asking my doctor for an alternative?
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I suffered from anxiety as a side effect of a postnatal thyroid condition - my child is now 18 months old. I was treated with Citalopram and my thyroid condition was treated successfully. After weaning sensibly off Citalopram before Christmas I was feeling fine but still not 100%. I was given Trimethoprim for a suspected UTI infection last week and the next day I suffered a full on anxiety attack whilst at the shops. I seemed to get more anxious by the day, and my physical symptoms got worse - raging thirst, swollen and white furry tongue, aching limbs but numbness all down my right leg, numb fingers, clumsiness, tearful and felt slow mentally - my speech even became affected. The lower back ache that prompted the urine test got more persistent and I now have a pain in my left hip socket. I thought I was suffering from MS which only heightened my anxiety. I didn't really connect it with the antibiotics. I then looked on this website and saw a LOT of negative comments regarding this drug. I stopped on day 5 and went to the doctor yesterday feeling very tearful. I was then given 20mg Citalopram and some painkillers and was told it was probably a trapped nerve and not down to the antibiotics. The worse thing was that my urine sample had been normal so needn't have taken it in the first place!! I took one Citalopram yesterday and was completely spaced out and felt sick. Luckily my husband took a day off work but I can't function like that as a full time mum to a toddler. What I would like to know is has anyone had an experience like this and should I wait a few days to see if I feel better without the Citalopram, in the hope that the anxiety was caused by the Trimethoprim. Ideally I don't want to start Citalopram only to go through withdrawal etc. We also want to add to our family at some point so ideally want to be drug free. Am considering a more herbal approach if the anxiety presents itself again like St Johns Wort
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I'm currently suffering from a Uti that causes me to Urinate litres of water and I was given a seven day course of Trimethoprim when the doctor found bacteria and blood in my urine. It been 48 hours since I started and I have had 5 of the tablets. There has been no difference, should it have already started? I'm male, which may mean that it takes longer to work than say a women in this situation.
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