Neurology :: Muscle Fatigue And Perceived Weakness And Twitching


Sep 27, 2014

I have been having a slew of health problems recently but am still awaiting further testing. In the meantime, I am very stressed and having a hard time managing. I keep getting worried that my symptoms could be onset of ALS despite knowing how illogical it sounds. I am a 25 year old male.

First, I was diagnosed by my doctor with a sinus infection, although it was probably very slight. She prescribed me Augmentin and I took it for 5 days and immediately started feeling bad on it. After I quit taking it, I noticed some tingling in my hands and feet at work on Thursday the 11th. The next evening, Friday, my legs started to feel unsteady and heavy when I walked and my hands and arms remained tingly and had perceived weakness. On Monday morning, the 15th, I went to the ER and they believed I had Lyme Disease and prescribed me doxycycline. I took this for 7 days, but did not feel any better. I remained having perceived weakness primarily in my legs accompanied by muscle tightness, muscle soreness, and very slight, sporadic twitching all over. On the 19th, I saw a neurologist who dismissed my symptoms as not serious as my reflexes were ok (knees were slightly weak, but I was very tense during the test) and I was able to walk normal, it just felt strenuous. My lyme test came back negative and a second western blot also came back negative.

Currently, I continue to have all of my symptoms, including perceived weakness, muscle fatigue, soreness, tightness, and twitching.  Symptoms are present all over my body, but concentrated in my legs. When I lay down at night, my whole body will feel as if I had a sunburn and I am having difficulty sleeping because of my worrying. If I go out and walk, my legs gets very sore and tired much quicker than they ever did before. Additionally, I have been having a very dry mouth and tight feeling throat. My PCP believes it to be either post-viral syndrome, mild MBS, or the least likely, MS. Others have suggested b12 or vitamin d deficiency. I have an MRI scheduled next week and an appointment with a different neurologist.

Other info:

-Was prescribed zoloft and am less than one week in to taking it. I believe it may be increasing the shakiness of my hands and my stress, as it takes some time to adjust to it.

-Was prescribed ambien to sleep. I'll sleep for about four hours straight, but then have a hard time continuing to sleep once I wake up. I believe I might be twitching or jerking in my sleep which wakes me.

-I tried to go to the gym on the 24th and run and lift weights. The next day, it felt like it really set me back, as I was much more sore and my legs seemed more unsteady.

-Began taking b12, b complex, magnesium, D vitamins.

-Had multiple blood tests. The only abnormal result was a positive ANA for speckled at 1:80. I read this can be a pretty common result.

-Less than 2 years ago, I had shingles.

Any thoughts on what could be wrong with me?

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I am 27 years of age. I have always been physically active through gym workouts and soccer. About a couple of weeks ago I came back from a trip to Texas and started feeling lightheaded and minor headaches (possibly from drinking for a couple of days). A week later the ALS bucket challenge started spreading around social media, ******** more than anything. So I decided to donate for the cause. After donating, I went ahead and decided to educate myself on the disease and the symptoms.

That was probably the worst idea ever. A couple of days later I felt muscle soreness/weakness in my legs, arms and back. Then the twitching started in both of my legs (quads, calfs and bottom of my feet), arms (triceps areas and behind my shoulders). My initial reaction was ALS/MS, and I started freaking out. I went through a 3 day period in which I lost my appetite and felt fatigue,drained and had no desire to do anything at all. It has been a week now and the twitching has not gone away. I decided to go to the doctor and got some lab work done. The doctor stated that everything looked great. He even conducted a physical neurological exam and I passed. He stated it could be stress or dehydration. However, I have always tried to drink plenty of water during the day (at least 4 glasses a day). He recommended over the counter calcium 500mg and vitamin D 1,000 units.

My lab work came back normal (hemogram, BMP fasting, ALT, AST, TSH) but my body is still twitching and it feels sore at times. Yesterday, I got home and felt weakness on the top back of my right calf. I very concern and not able to concentrate on my daily activities (work and personal related activities).

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I have pets and they play in a backyard that is filled with squirrels, rats, opossums, and birds. I sleep with one of my dogs and I have found a few ticks in my bed before. I didn't think they bit humans but about 2 months ago I did develop a weird rash on my upper buttox that became a huge cyst (I sleep belly-down). It lasted a few weeks but it completely disappeared a couple of weeks ago. I just thought it was a big zit and didn't think much of it. Maybe this could have been a bite?

Sorry, about the long read. I am a recently discharged disabled veteran and I receive healthcare through the VA. Appointments are always weeks away due to huge backlogs, which makes it even more frustrating. The appointments are also always rushed and my doctors are quick to make the "anxiety" diagnosis if they don't find anything obvious.

I am not looking for a diagnosis. I am mainly seeking advice on what I should do and if my symptoms may sound like Lyme. I would also like to ask how I can approach my doctor with the possibility of Lyme Disease without being dismissed right away. I am really starting to get scared because I have been getting progressively worse over a period of almost 2 months.

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Autoimmune Disorders :: Muscle Weakness

I am a 29 year old female and I was diagnosed with Hashimoto's Thyroiditis at the start of the year. I have been having problems with my right eyelid in that over the course of the day it progressively becomes droopy and the only thing that relieves it is when I close it. When it becomes droopy it makes my eye feel like there's something in it and I end up rubbing it. It's only when I look in the mirror that it's droopy.

In January  my endocrinologist ran an autoimmune profile (but not for every single antibody) and rheumatoid factor and these are the results of it:

Rheumatoid Factor - 9IU/mL (<20 negative)

HEP2 - Positive

Type - Speckled

Anti-DSDNA - 7IU/mL (<30 negative)

(Positive antinuclear antibodies but no significant disease association found)

ENA screen - Negative

Autoimmune profile

Antinuclear Abs - Positive

Anti-Smooth muscle Abs - Negative

Anti-Parietal Abs - Negative

Anti-Mitochondrial Abs - Negative

Anti-LKM Abs - Negative

Anti-Thyroid Peroxidase Abs (Anti-TPO) - 141 kIU/L (<34 negative)

I am posting here because I have a suspicion that I have Myasthenia Gravis. Not only have I got the problem with my eyelid but I tried to follow some physical tests for muscle weakness such as holding my arms out straight in front of me and deep knee bends.The results of these home tests I did:

Holding out arms stretched in front for 60 seconds - pain in both arms when it came up to the 60 seconds and left arm dropped slightly

10 deep knee bends - did all 10 knee bends but the last 3 made my legs feel weak and shaky

5 sit-ups (sitting from lying down) - could only manage 4 sit-ups

I have an appointment with my GP on Friday and since this has now appeared I'd like to mention my concerns to them.

My main concerns are :

Wouldn't my endocrinologist have tested me for Myasthenia Gravis if it's an autoimmune condition? If so what antibodies would she have tested and would any of the ones I had tested have shown I have Myasthenia Gravis?

Who do I need to request to see to get a confirmed diagnosis?

If it is indeed Myasthenia Gravis would it be because my current autoimmune condition made it worse? I have read that this is possible and I became very hypothyroid yesterday as I had very bad Reynaud's flares when out and about.

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Help! In 2001 I had a thyroidectomy. Immediately, my blood pressure, (which had always been remarkably low), shot through the ceiling and I've been on BP meds ever since. But I digress...

I was always super active. I skied, ran, kite boarded, hiked, biked... all a healthy and important part of my life. I even had booked a trip to climb Kilimanjaro for my 60th birthday in 2010 when I came down with Swine Flu, followed by a couple bouts of pneumonia. When I recovered, I tried to go back to skiing about three months later and found that I had lost muscle strength! I couldn't make turns (and that's a bad thing...) I got weaker and weaker. My doc had no clue. We checked heart, lungs. I was at low end of thyroid and adrenal levels, but "not a problem", I'm told. I'm not a drama person at all, but I really began to believe I was dying because I was getting weaker and felt like my energy was draining away.

At wit's end, I went (for the first time) to a brilliant naturopath who drastically improved my already good died and put my on Chinese meds. It took about three months, but I eventually stopped getting weaker and became stable. That was HUGE! Since, however, I've remained pretty stable and we keep trying other things but nothing has put me even close to where I was.

The best guess is that its related to thyroid or adrenal function. I dunno...

I can now make between 6-10 stairs before I have to stop for a few seconds to regroup. I can swim very short distances but never alone because when I run out of energy, its GONE and I have absolutely nothing left. This has drastically impacted my life and I want to be strong again!

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