Mirtazapine Withdrawal - Anxiety Coming Back


Sep 28, 2014

I have been taking 15mg of mirtazapine for 6 months for sleep problems and anxiety.

It has helped me sleep and feel more relaxed. But have struggled with word retrieval and foggy head. I decided to come off it and have been on 7.5 mg for 4 weeks, I have been doing ok but the last three days have had problems sleep waking after 3 hours and my anxiety feels like it coming back! Is this just withdrawal or am I going back my old ways?

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I've gone from 30 mg for 8 months to 15 mg 9 days ago to 7.5mg 3 days ago.

So far(touch wood) i feel fine but i'm concerned with all the bad experiences some people have had during coming off this drug.

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This is where it doesn't go too well.

The side effects have been awful.Dizziness,moody,headaches and lethargic.I didn't expect them to be this bad.

I've persevered and I am feeling stronger than ever.

How long will the dizziness go on though?

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Coming Off Mirtazapine And Weight Gain

I'm already taking Pristiq however was having episodes of anxiety, panic attacks and insomnia and so my doctor also prescribed me mirtazapine. In some ways it has been a miracle, as somebody suffering from severe social phobia it has helped me to open up a little to the outside world and even attending social outings which is not like me. I feel far less stressed as well. I WISH I could stay on it!

The problem I am having is I've put one a huge amount of weight in the month or so I've been taking it. I've put on at least 7kg but probably more by now, I am visibly much fatter, and being a bit overweight in the first place (and wanting to lose weight) means this far outweighs the benefits. I suddenly have a huge appetite and I cannot control my eating, it is becoming a real problem. I've read people say to get over it and simply control your eating but it isn't that easy, before I even try a strictly healthy diet, I need to get off these pills and give my body a chance to get over these cravings.

My first question is, if I were to stop taking mirtazapine, or even start taking one every 2nd day to eventually taper off, can I expect any awful side effects? I have big exams in a week and I don't want to risk nasty side effects, however I'm really worried I will just keep stacking on the weight even in that short week, I want to get off them ASAP. I haven't been on them all that long so am wondering if I will experience anything bad if I cut back on them. My other antidepressants cause me vertigo if I miss a pill.

Second question, has anyone had any luck with other anti-depressant or anti-anxiety medication that helps with general/social anxiety, that does not cause weight gain? I know everyone reacts to medications differently but I'm just interested to see if there is an alternative to mirtazapine without this one (seemingly very common) side effect. 

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I have been on 30mg mirtazapine for four years. I tried to come off them a couple of years ago and failed miserably, returning to my full dose after 10 days of awful anxiety and insomnia, as well as migraines and nausea. I had cut my dose to 15mg for a week and then dropped to zero.

This time I read every thread on here about mirtazapine withdrawal and started off really slowly, cutting down by just 3.75mg for two weeks. Then by a further 3.75 mg. At the same time I started taking a lot of inositol. I take a huge heaped teaspoon in my tea every morning. I had only slight nausea when I first started dropping my dose but I think that was me getting used to the inositol. Once I was down to 22.5mg of mirt, with no withdrawal symptoms, I figured I could go a bit faster and dropped my dose down to 15mg. I had no withdrawal symptoms after ten days and so have now dropped my dose to 11.25mg. I use a simple pill cutter from ebay to cut my tablets. So I am now on three quarters of a 15mg tablet. Mirtazapine had pooped out on me and so I already have terrible insomnia. I take temazepam some nights and benadryl on others to help me with that.

I will post my progress here. Who knows, I may fail miserably, but whatever the outcome, I hope it will help others. I was terrified of coming off mirtazapine, but now I am excited by it. I think the key is to take it really slowly and work out the pace your body can cope with. The smaller your dose goes, thee smaller the decrease in your dose should be. Good luck everyone, and please post your own experiences here. I know some people have really suffered despite coming off mirt very slowly. Everyone is different and I think everyone's experience can be a real help to others.

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My questions now:

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2) did anybody experience huge volume of stool every day - all the time while on Mirtazapine?

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Withdrawal - Mirtazapine :: Is Addictive And I Was Addicted

Having read some of the experiences others have had withdrawing from Mirtazapine I thought I would post my own. I hope it may be of use to others. I recently was re-prescribed Mirtazapine,after three years of not taking it. I took one 15mg tablet, felt like I'd been hit over the head with a riot shield and fell out of bed with severe restless legs syndrome. I decided there and then "there is no way I am going through all this again", and stopped it right there.

Previously, I had been prescribed Mirtazapine for severe anxiety and depression. This medication caused restless leg syndrome, and caused me to put on 3 stones in weight. Despite being previously a fit and active person. I became lethargic, and fatigued easily, needing to rest after evey 20 minutes of moderate activity, not to mention the dreadful hangovers I would have all morning. I persisted in taking it for nearly 5 years because I looked forward to the sedative effect it has. I even looked forward to it at night, despite the dreadful side effects, because I felt it helped me escape the world into sleep. Personally I think Mirtazapine is addictive and I was addicted.

I eventually decided enough was enough and decided to get my life back.

My GP was of little use when it came to advice for tapered withdrawal, though damn quick to prescribe the stuff in the first place. I determined an action plan of my own. I was aware of the unpleasant withdrawal symptoms of suddenly stopping, as I had previously, on occasion, run out of money and couldn't afford my prescription. Dizziness, extreme anxiety, nausea, insomnia, sweating and flu like muscle and headaches are all in store for any one who stops this medication abruptly. I tapered Mirtazapine over approximately 3 months by, cutting up 30mg tablets. 1st week I took 3/4rs of a tablet, then 1/2 plus an 1/8th second week, then 1/2 plus 1/16th for the 3rd week and so on. Eventually I was taking 1/16th of 30 mg (or less) per night for the last 2 weeks after which I felt no withdrawal symptoms upon cessation. The doses are approximate as cutting these tablets is accurately is difficult.

All of this took a lot of focus and bloody-minded determination. I find it surprising that the manufacturers don't provide decreasing doses for people wishing to stop taking their product without discomfort. At the moment I have decided to cope with life without Mirtazapine, or any other chemical horror. It can be very difficult at times, but vastly better than being a Drs. corporate guinea pig/junkie. I would say though, that for people who are severely depressed, Mirtazapine or other medications could be helpful if used for the short term, but please be aware of the very real side effects and problems with these substances. Ask yourself very carefully if you think you need this, despite what your Dr. may say. These drugs should be a last resort, not first port of call. They most certainly are no magic cure, and have serious "side effects" that should not be underestimated.

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I broke my wrist on 1st Feb and my body went into severe shock. I felt very ill and couldn't sleep. My doctor gave me Mirtazapine to "calm things down". I took two 15mg tablets a day for 7 days and had horrible reactions including 'burning' and painful legs. I just stopped taking them 18 days ago but ever since I have what I imagine must be withdrawal symptoms. I feel so ill and feel desperate for some reassurance that things will pass. I can't sleep,feel nauseous,my chest hurts and I feel breathless. The symptoms seem to be getting worse.

I am so shocked that I have such a severe reaction after only taking the tablets for a week. Can anyone out there tell me if this is normal?

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Mirtazapine Withdrawal - What Symptoms To Expect?

I would like to ask anyone who has withdrawn from Mirtazapine to explain what sort of symptoms you have experienced with withdrawal.

I have reduced from 15 mg to 12.5mg 4 weeks ago and have had a constant trembling/ shaking feeling predominantly in the mornings with an underlying anxious feeling, nausea, gastric upset, sweating, aching lower limbs and pressure in my head. Can anyone relate to any similar effects please?

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