Hepatitis B :: Gilead's Hep B Drug As Effective As Viread But Safer
Jan 6, 2016
There is a link about tenofovir alafenamide (TAF).
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Jan 6, 2016
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Gilead Submits TAF NDA For Hepatitis B
Gilead Sciences (NASDAQ:GILD) files its New Drug Application (NDA) with the FDA seeking clearance of tenofovir alafenamide (TAF) 25 mg for the treatment of adults with chronic HBV infection. The company is transitioning its product line to TAF from TDF (tenofovir disoproxil fumarate) because it is just as effective at a dose less that one tenth that of TDF and is less stressful on the bones and kidneys.
The company intends to file its TAF Marketing Authorization Application (MAA) in Europe this quarter.
Hepatitis C :: Gilead - Next Generation Of Harvoni?
Has anyone heard of a new drug in the works from Gilead, which is supposed to cure hep c in geno 1a patients with cirrhosis, having pre-treatment and null responders.
View 2 RepliesHepatitis B :: TDF (viread) Experiences Anyone?
After 1month of viread, my alt increased from 200 to 373.
Before:
Hbv DNA 170 million
As I said my Sgpt 200
Hbeag reactive
After 1 month
Hbv DNA 133,000
Hbeag reactive
Sgpt 373
My alt increasing is this normal?after 2 more months what will be next happen to my sgpt.please share with ur tdf experienced.
Hepatitis B :: Viread Treatment
I have been diagnosed with Hep B. I was admitted to hospital with exceptional readings (ALT >4,000, bilirubin 180, all pho 162, gamma get 417, AST >2,500). I've been given various drips and the numbers are coming down. ALT has now halved. In addition to the drips I was also put on Viread.
My physician was concerned how my immune system was attacking the liver and between all treatments, in three days the readings are coming down. My jaundice is going and my urine now looking paler (almost normal).
Given the symptoms indicate a severe acute response to infection, does this suggest my body will put up a good fight to rid itself of the virus. Also, is there a risk Viread could actually lead to my body not developing the antibodies? I've read the following study, which suggests Viread can be highly effective in treating severe acute Hep B and also assist (or at least not inhibit) the development of antibodies.
Hepatitis B :: 3 Months On Viread DNA Positive < 20 Iu/ml
I ve been on viread for 3 months. The latest hbv dna is positive <20 ıu/ml. Before viread I was on lamivudine and hbv dna was generally again positive <20 ıu/ml. I think it was 3 times undetectable at different times. Alt Ast normal afp normal. Do you think dna will be und next time? If it comes positive again what. treatment or evaluation can you recommend ? I also started to take vit d3 daily 10 days ago.
View 6 RepliesHepatitis B :: Viread Side Effects?
I have hepatitis b infection in the liver. I need your advise if I should take viread medication if I have osteopenia and my kidney is not the best? I am currently taking osteopenia pill. Please advise and help. Thanks a lot. I am worried about viread side effects on me. Another question is if I take the medicine, can I ever stop taking the medicine? Is it a life term medicine I have to take?
View 1 RepliesHepatitis B :: Viread Results After One Month
I want to know..if continue taking this..viread.my liver is going to serious damage?.my lab result before taking viread.
Hbv DNA - 170 million
Sgpt - 200
Hbeag - reactive
After 1 one month of taking tdf.
Hbv DNA - 100,000 something..
Hbeag - reactive
Sgpt - 337
Hepatitis B :: Is Viread A Safe Medicine?
My Doctor prescribed a viread/ tenofavir.shall i take it.Is it a safe antiviral drug.What can i expect as a side effects?
View 2 RepliesHepatitis B :: Viread Generic Or Brand
My doctor let me have Viread. I checked online at pharmacy checker. Tenofovir Disoproxil Fumarate Tablet and Viread Tablet, are they the same in treatment wise? I went to CVS store, it cost 1000 USD to 30/300mg for Viread Tablet. is it too expensive? The staff there told me generic tablet is not available. But why I see it online as I said earlier?
What happens if I take brand and then switch to generic like a year later? Will the generic medicine do the same?
Hepatitis B :: Viread And Hair Loss
So I've been taking viread before bed for the last 4 years. My hair has been receding and falling out throughout those years. It is now getting really aggressive and noticeable. I stopped taking viread for a month to see if it would reverse and sure enough it did. It came back full and thick. Yesterday I took viread again and half of what came back began falling out. Does anyone have any tips or suggestions? I'm still young and my parents have good hair. What can I do to stop or prevent? I tried taking biotin but it seems its not enough
View 16 RepliesHepatitis B :: Nails Discoloration After Starting Viread
Has anyone experience nail discoloration after starting viread?
View 11 RepliesHepatitis B :: ALT Increase After Stopped VIREAD 3 Weeks
I just had my second child 7 weeks ago. I stopped taking VIREAD FOR 3 weeks after gave birth because of breastfeeding. But ALT was increased to 53. Then I continue to take VIREAD but now the ALT is still 53. I remember this medicine can control liver function very quick when I started to take it years ago. is it possible the medicine doesn't work on me anymore? anybody can explain?
View 1 RepliesHepatitis B :: Hep B DNA Flare Up During Tenofovir Treatment/viread
When I first began treatment with pegasys in january 2014, GGT was 60 (normal max is 35), ASAT 51 (normal max 35), ALAT 76 (normal 10-40), LDH/Bili/CK all within normal range. With pegasys, a few months later down the line, the values continued to go higher. At their highest, GGT 223, ASAT 116, ALAT 156, LDH 274, Bili/CK remained within normal range.
At the beginning of the treatment, Hep B ie/ml was 2400. Four months later, it became 2600. When I was shifted to tenofovir/Viread three or months after beginning treatment since pegasys wasn't solving the issue, the ASAT, ALAT, LDH came back down to normal levels quite fast. So I have been on viread ever since.
10 months after beginning treatment, Hep B ie/ml was down to 1800. In 2015, it was less than 150. Hep B Dna was undetected by May 2015. I get regular blood tests every three months since the start of the treatment.
Yesterday's blood test showed: ASAT 36 (normal max 35), ALAT 38 (normal 40, but having checked past blood tests, it seems in the last few months it has been gaining one or two points steadily so this is worrying me), LDH and Bili are normal. The bad news: Heb B DNA detected...and IE/ml was a whopping 3400!!!! More than when I started started treatment!
The first thing I was asked was whether I missed a dose of viread. Answer is no. However, I have had incidents where I did forget to take it on time, but it has never exceeded 5 hours (still, I know, it's a huge gap). Not a lot of times, but I find that I am beating myself over this now, as it may be the reason I am having a viral overload and maybe made the virus resistant to viread.
Since taking viread, I have experienced and continue to experience extreme muscle pain (I ended up in the hospital once when diclofenac failed me and I needed an extra morphine shot to get relief). I am continuously tired, some days it is a real struggle to move (feels like going through mud - heavy body, wanting to simply just crash on the floor). I have not had a pain free day in the last two years and worse, kidney stones! I am already prone to them, but I can't get over the suspicion that Viread has ensured I have a stone that needs to be taken out each year.
I've read that viread is one of the best treatment there is (hardly any side effects, probability of virus resistance low) so my latest blood test is worrying me no end. I am not due for another DNA test until 6 months later. I've also read that ASAT and ALAT values can increase and it's not necessarily liver related (I think my ongoing and increasing muscle pain is reflecting higher ASAT and ALAT values but who knows?!?).
My doctor says that as long as those values remain within normal range and not in the hundreds, it should be ok. But there is this unspoken thought that I am in deep trouble if the DNA continues to manifest and my liver enzyme values continue to increase. My liver scan in 2014 has me a point JUST before entering cirrhosis stage. I can't help but think I may have actually crossed that line already (the cassandra in me speaking) though I am assured that viread treatment tends to pull back the damage.
My question..Has anyone ever experienced a viral increase during the viread treatment, and if so, was it temporary, or was viread stopped? I am not sure how to read/interpret this ie/ml, but the fact that it has increased can't be good news at all.
Hepatitis B :: Viral Load Still Around 200 IU After 3 Years Of Viread
I have been on Viread for three years and my viral load never goes undetectable. The viral load went down in the past two years. However, it has been up and down in the range of 100 to 300 IU in the past year. It seems that it will never go down to undetectable. The test for mutation failed three times because of very low viral load. Am I non-responder to Viread? Should I switch to another treatment? Should I be concerned?
View 13 RepliesAlcohol And Drug Misuse :: Drug Urine Test
I'm a bit worried. I had a urine test at work but forgot to mention that I had some antibiotics about 3/4weeks (maybe more) prior to the test, the antibiotic was penicillin VK.
I've read most antibiotics stay in your system for up to around 4-8 hours, especially penicillin VK. Some other sources reckoned between 7-10 days max. Although most said up to about 8hours max.
So I'm wondering if this would show up in the test at all?
Hepatitis C :: 66 Years Old With Reactive Hepatitis
my father is 66 years old, it has been found out through blood test (ANTI HCV) his cutoff value is 1.00 and patient value is 12.51. which further reveals reactive hepatitis. what do you suggest for him?
View 1 RepliesLansoprazole :: Effective For Gout ?
i have just been prescribed lansoprazole for gout, how will this help?
View 1 RepliesOmeprazole Vs. Lansoprazole - Which Is More Effective
I have the option to use either for triple therapy to treat a stomach infection (h.pylori)
Omeprazole 20mg 1 tab twice daily
Lansoprazole 15mg 2 tab once daily before dinner
Which one would be more effective? If I have to suffer more so be it. I want this thing gone.
More Effective - Simvastatin Or Lipitor?
after I had my last physical exam for work I was bit surprised when the doctor informed me my blood tests showed that both my cholesterol and triglyceride levels were borderline high and that I should go talk to my physician about my option for lowering those. Otherwise I passed with flying colors - I’m not overweight and I exercise twice a week.
My physician gave me several more guides on the diet, of course I’m continuing with my exercise regime, but he also told me he thinks I should think about starting statin medication, either simvastatin or Lipitor in his opinion. Which one of these is more effective?
Eye :: Laser To Get Rid Of Floaters - Effective?
QUOTE FROM ARTICLE:
Although the idea of a clinic-based YAG laser operation is alluring for its perceived simplicity, we have the following concerns.
1. The energy delivered into the eye is not acceptable. The energy delivered to the eye in YAG vitreolysis compared with standard YAG capsulotomy is much greater. Van der Windt and colleagues state the typical required power is 2.5 mJ to 4.5 mJ, and they do not recommend exceeding 500 pulses per treatment session. They recognize multiple treatment sessions may be necessary. It is our opinion this level of energy being delivered into the eye is too great, putting the patient at unnecessarily high risk for postoperative inflammation, glaucoma and retinal tear/detachment.
2. The efficacy of YAG vitreolysis is also in question. Delaney and colleagues found that 38% of patients treated with YAG vitreolysis had a moderate reduction in symptoms while 62% had no improvement.
The alternative treatment for YAG vitreolysis, and what we recommend at Mercy in carefully selected cases, is small-gauge pars plana vitrectomy. This procedure yields much higher efficacy. In the same Delaney study, they reported 93.3% of eyes undergoing vitrectomy for floaters resulted in full resolution. By utilizing modern surgical equipment, now readily available in as small as 27 gauge and cut rates as high as 7,500 cuts/minute, very little energy is directed into the vitreous, and very little traction on the vitreous is exerted. Vitrectomy has the advantage that if a retinal tear develops intraoperatively, it should be easily identified and treated at the end of the case.