Lexus ES 2007-12 :: 2009 - Tons Of Light Popped Up On The Dash / Misfiring

2009 ES350. Couple of months ago I have driving down the high way and a ton of light popped up on the dash. (CEL tracking VSC) After another 50 miles it developed a miss. Next morning the miss went away and it but all the lights were still on. Auto zone said misfire so I figured I need to change plugs(65k on the motor) well 100 miles into coming home the mis fire comes back. and we make it home. Next day same thing.....

I change the plugs.... disconnect the computer and it was good for a couple hundred miles and BAM!! it starts all over. CEL on... I noticed if I stay city driving it doesn't get to the miss fire point. but if I do any kind of highway driving it'll eventually develop a miss.

I check it again and it showed 2 and 4 mis fire, I picked up 3 coils put them all on the front. It ran good for 350 miles and bam here it is again. Last Sunday I started up the car and it just started misfiring at idle. well I went to check it at autozone coz it was really bad. and it had 4 cylinders misfiring total.

Well in the mean time getting it checked the light were on it wouldn't start. so I just bought a battery. (it had been having battery issues over the last couple months) I don't want wifey to be stranded somewhere with the baby.

I'm new to these news lexus's.. Ive had 2 Is 300's and my daughter has a gs 300. Do I need to use a specific spark plug for the 350? Would the dying battery contribute to this?

I did find the air box was not closed properly by the oil change company wifey uses. so I thought that was an issue but it cam one at the 350 mile mark. What else to try..